{"id":4864,"date":"2025-05-30T10:10:40","date_gmt":"2025-05-30T10:10:40","guid":{"rendered":"https:\/\/lasamclinic.com\/?post_type=product&#038;p=4864"},"modified":"2025-06-21T10:26:03","modified_gmt":"2025-06-21T10:26:03","slug":"actuator","status":"publish","type":"product","link":"https:\/\/lasamclinic.com\/en\/product\/actuator\/","title":{"rendered":"Rejuvenating Skin Actuator 30ml"},"content":{"rendered":"<h3>INTRODUCTION<\/h3>\n<p>Skin appearance and texture are strictly dependent on the proper biosynthesis of biomolecules by fibroblasts. These cells continuously renovate the matrix surrounding the dermal cell population by orchestrating the synthesis of collagen and elastin. As a result, they support the structural integrity and elasticity of the skin.<\/p>\n<p>The biosynthetic machinery is activated mainly by certain proteins, among which growth factors play a key role. However, ageing and environmental factors can compromise fibroblast function, creating a need for interventions that restore their regenerative capabilities.<\/p>\n<p>The ACTV8SKN\u2122 Actuator, powered by SIGMOLECS peptides\u2014synthesized to mimic human growth factors\u2014was developed to promote renovation pathways and counteract ageing processes.<\/p>\n<p>This research investigated the impact of the Actuator on the signalling pathways governing COL1A1 and ELN cellular expression, as well as its efficacy in improving skin appearance, in comparison with a growth factor-enriched competitor product (CP).<\/p>\n<p>Home Use \u2013 morning and evening or as needed especially after laser.<br \/>\nGently apply a few drops of the Actuator to your cleansed face. Lightly spread the drops to cover the desired area with a thin layer.<br \/>\nThe fluid gel will absorb as soon as it is spread.<\/p>\n<h3>INGREDIENTS<\/h3>\n<p>SIGMOLECS\u00ae<br \/>\nSH-oligopeptide-1<br \/>\n\u2022 SIGMOLECS\u00ae<br \/>\nSH-oligopeptide-2<br \/>\n\u2022 SIGMOLECS\u00ae<br \/>\nSH-polypeptide-1<br \/>\n\u2022 SIGMOLECS\u00ae<br \/>\nSH-polypeptide-42<\/p>\n<h3>Indications<\/h3>\n<p>Pre i posle procedure \u2013 laser, mikronidling, hemijski piling, PRP, fileri.<\/p>\n<h3>Patient benefits<\/h3>\n<p>More elastic, bright and hydrated skin. Protection from environmental stress. Sustains regenerative treatments between appointments and as a regular anti-aging plan.<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-medium wp-image-5273\" src=\"https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-1-300x143.png\" alt=\"\" width=\"300\" height=\"143\" srcset=\"https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-1-300x143.png 300w, https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-1-18x9.png 18w, https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-1.png 611w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><img decoding=\"async\" class=\"alignnone size-medium wp-image-5274\" src=\"https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-2-300x127.png\" alt=\"\" width=\"300\" height=\"127\" srcset=\"https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-2-300x127.png 300w, https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-2-18x8.png 18w, https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-2-600x256.png 600w, https:\/\/lasamclinic.com\/wp-content\/uploads\/2025\/05\/ak-2.png 607w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>","protected":false},"excerpt":{"rendered":"<p>A double evaluation, in vitro and in vivo, of a\nhydrogel-dispersed mixture of human\nsynthetic biomimetic peptides (ACTV8SKNTM\nActuator) to modulate COL1A1 and ELN\nfibroblast gene expression and to modify skin\nappearance and texture, in comparison with a\nsimilar GFs-enriched product.<\/p>","protected":false},"featured_media":4865,"comment_status":"open","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":""},"product_brand":[],"product_cat":[54],"product_tag":[],"class_list":{"0":"post-4864","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-contrad-swiss","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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